A Textbook of Medicine Tenth EditionPDF电子书下载

The Infectious Diseases 1

VIRAL DISEASES 1

INTRODUCTION＆Frank L．Horsfall，Jr 1

COMMON UPPER RESPIRATORY DISEASE＆Yale Kneeland，Jr 2

THE COMMON COLD 3

ADENOVIRAL INFECTIONS 7

ACUTE UNDIFFERENTIATED RESPIRATORY DISEASE(＂ARD＂) 8

NONSTREPTOCOCCAL EXUDATIVE PHARYNGITIS 9

PHARYNGOCONJUNCTIVAL FEVER 9

INFLUENZA＆Frank L．Horsfall，Jr 10

DENGUE＆R．Walter Schlesinger 14

COLORADO TICK FEVER＆Lloyd Florio 16

YELLOW FEVER＆J．Austin Kerr 18

MEASLES＆Edwin D．Kilbourne 20

RUBELLA＆Edwin D．Kilbourne 25

CYTOMEGALIC INCLUSION DISEASE＆Edwin D．Kilbourne 27

HERPES SIMPLEX＆Frank L．Horsfall，Jr 27

VARICELLA；HERPES ZOSTER＆Joseph Stokes，Jr 28

SMALLPOX＆Joseph Stokes，Jr 30

VACCINIA＆Joseph Stokes，Jr 36

MUMPS＆Gordon Meiklejohn 40

PSITTACOSIS＆Frank L．Horsfall，Jr 43

LYMPHOGRANULOMA VENEREUM＆Virgil Scott 45

FOOT-AND-MOUTH DISEASE＆Walsh McDermott 47

LYMPHOCYTIC CHORIOMENINGITIS＆Charles A．Janeway 48

RABIES＆Hilary Koprowski 50

COXSACKIE AND ECHO VIRAL INFECTIONS＆Robert J．Huebner 54

HERPANGINA 55

EPIDEMIC PLEURODYNIA 57

＂ASEPTIC MENINGITIDES＂DUE TO COXSACKIE AND ECHO VIRUSES 58

EXANTHEMATA AND＂ASEPTIC MENINGITIS WITH RASH＂DUE TO ECHO VIRUSES 59

MYOCARDITIS NEONATORUM 59

PREVENTION OF COXSACKIE AND ECHO VIRUS INFECTIONS 60

POLIOMYELITIS＆John R．Paul 60

ENCEPHALITIS LETHARGICA＆Frank L．Horsfall，Jr 70

ST．LOUIS ENCEPHALITIS＆Frank L．Horsfall，Jr 71

POSTINFECTION ENCEPHALITIS＆Frank L．Horsfall，Jr 72

EQUINE ENCEPHALOMYELITIS＆LeRoy D．Fothergill 74

THE DISEASE IN HORSES 74

THE DISEASE IN MAN 75

VIRAL DISEASES(PRESUMPTIVE) 77

EPIDEMIC HEMORRHAGIC FEVER＆David P．Earle 77

INFECTIOUS MONONUCLEOSIS＆John Seward Lawrence 80

CAT SCRATCH DISEASE＆Worth B．Daniels 83

ACUTE INFECTIOUS NONBACTERIAL GASTROENTERITIS＆Irving Gordon 85

RICKETTSIAL DISEASES 87

INTRODUCTION＆John C．Snyder 87

THE TYPHUS GROUP＆John C．Snyder 89

EPIDEMIC LOUSE-BORNE TYPHUS FEVER 89

BRILL-ZINSSER DISEASE 93

MURINE FLEA-BORNE TYPHUS FEVER 95

ROCKY MOUNTAIN SPOTTED FEVER＆Joseph E．Smadel 97

SCRUB TYPHUS＆Joseph E．Smadel 103

RICKETTSIALPOX＆Joseph E．Smadel 107

Q FEVER＆John C．Snyder 109

TRENCH FEVER＆Henry Pinkerton 111

BACTERIAL DISEASES 113

PNEUMONIA 113

PNEUMOCOCCAL PNEUMONIA＆W．Barry Wood，Jr 113

PNEUMONIA DUE TO VIRAL AGENTS＆Harry M．Rose 130

PNEUMONIA CAUSED BY KNOWN VIRUSES AND RICKETTSIAE 130

PNEUMONIA CAUSED BY UNIDENTIFIED VIRAL AGENTS OR AGENTS PRESUMED TO BE VIRUSES 131

PRIMARY ATYPICAL PNEUMONIA 132

STREPTOCOCCAL INFECTIONS 136

INTRODUCTION＆Lowell A．Rantz 136

HEMOLYTIC STREPTOCOCCAL SORE THROAT＆Lowell A．Rantz 141

ACUTE TONSILLITIS AND PHARYNGITIS＆Lowell A．Rantz 141

SCARLET FEVER＆Lowell A．Rantz 143

ERYSIPELAS＆Lowell A．Rantz 145

PERITONSILLAR ABSCESS＆Lowell A．Rantz 147

HEMOLYTIC STREPTOCOCCAL PNEUMONIA＆Lowell A．Rantz 148

RHEUMATIC FEVER＆Maclyn McCarty 148

STAPHYLOCOCCAL INFECTIONS 160

INTRODUCTION＆Charles H．Rammelkamp，Jr 160

FURUNCLES AND CARBUNCLES＆Charles H．Rammelkamp，Jr 161

STAPHYLOCOCCAL PNEUMONIA＆Charles H．Rammelkamp，Jr 162

OSTEOMYELITIS＆Charles H．Rammelkamp，Jr 163

STAPHYLOCOCCAL BACTEREMIA＆Charles H．Rammelkamp，Jr 165

ENTEROCOLITIS＆Charles H．Rammelkamp，Jr 166

GONOCOCCAL INFECTIONS 166

GONOCOCCAL INFECTIONS＆William M．M．Kirby 166

MENINGOCOCCAL INFECTIONS 170

MENINGOCOCCAL INFECTIONS＆John H．Dingle 170

BACILLARY DISEASES 178

HEMOPHILUS INFECTIONS 178

PERTUSSIS＆William L．Bradford 178

HEMOPHILUS INFLUENZAE INFECTIONS 182

HEMOPHILUS DUCREYI INFECTIONS＆H．E．Alexander 184

GRANULOMA INGUINALE＆Walsh McDermott 184

DIPHTHERIA＆F．S．Cheever 185

CLOSTRIDIUM INFECTIONS 191

HISTOTOXIC INFECTIONS＆John D．MacLennan(Revised by Harry M．Rose) 191

Gas Gangrene 191

Clostridial Gastroenteritis 194

NEUROTOXIC INFECTIONS＆Harry M．Rose 194

Tetanus 194

SALMONELLA INFECTIONS 201

TYPHOID FEVER＆Paul B．Beeson 201

SALMONELLOSIS OTHER THAN TYPHOID FEVER 205

INFECTIONS WITH THE COLIFORM，PROTEUS AND PSEUDOMONAS GROUPS OF BACILLI＆Charles A．Janeway 210

KLEBSIELLA INFECTIONS(FRIEDLANDER＇S BACILLUS)＆Maxwell Finland 214

KLEBSIELLA PNEUMONIA 214

CHRONIC KLEBSIELLA INFECTIONS OF THE LUNGS 216

KLEBSIELLA SEPSIS 217

BACILLARY DYSENTERY＆F．S．Cheever 218

CHOLERA＆Francis R．Dieuaide 222

BRUCELLOSIS＆Wesley W．Spink 226

PASTEURELLA INFECTIONS 232

PLAGUE＆Francis R．Dieuaide 232

TULAREMIA＆Karl F．Meyer 235

GLANDERS 239

MELIOIDOSIS＆Karl F．Meyer 239

ANTHRAX＆Karl F．Meyer 240

ERYSIPELOID OF ROSENBACH＆Karl F．Meyer 244

MYCOBACTERIAL INFECTIONS＆J．Burns Amberson 245

TUBERCULOSIS 245

General Considerations in Clinical Diagnosis and Treatment of Tuberculosis 251

Specific Chemotherapy for Tuberculosis 255

Tuberculosis of the Lungs 262

Tuberculosis in Children 279

Tuberculosis of the Larynx，Trachea and Bronchi 280

Tuberculosis of the Alimentary Tract 281

Generalized Forms of Tuberculosis(Acute Generalized Miliary Tuberculosis) 282

(Subacute Forms) 283

(Latent and Chronic Forms) 284

Tuberculosis of the Serous Membranes 284

Tuberculosis of the Pleura 285

Tuberculosis of the Lymph Nodes 286

Tuberculosis of the Urinary Tract 287

Tuberculosis of the Genital Tract 288

Tuberculosis of the Meninges and Central Nervous System 289

Tuberculosis of the Special Structures 291

Prevention of Tuberculosis 292

DISEASES DUE TO ATYPICAL ACID-FAST BACILLI 293

LEPROSY＆Harry L．Arnold，Jr 294

BARTONELLOSIS Henry Pinkerton 302

THE MYCOSES 305

ACTINOMYCOSIS＆David T．Smith 305

NOCARDIOSIS＆David T．Smith 306

BLASTOMYCOSIS＆David T．Smith 307

GEOTRICHOSIS＆David T．Smith 308

COCCIDIOIDOMYCOSIS＆David T．Smith 308

SOUTH AMERICAN BLASTOMYCOSIS＆David T．Smith 310

CRYPTOCOCCOSIS＆David T．Smith 310

HISTOPLASMOSIS＆David T．Smith 311

CANDIDIASIS＆David T．Smith 313

SPOROTRICHOSIS＆David T．Smith 313

MADUROMYCOSIS＆David T．Smith 315

CHROMOBLASTOMYCOSIS＆David T．Smith 315

ASPERGILLOSIS＆David T．Smith 316

PENICILLIOSIS＆David T．Smith 316

MUCORMYCOSIS＆David T．Smith 316

RHINOSPORIDIOSIS＆David T．Smith 317

SPIROCHETAL INFECTIONS 318

SYPHILIS＆Walsh McDermott 318

CLINICAL PICTURE OF SYPHILIS 321

Late Syphilis 324

Syphilis in Pregnancy 326

SEROLOGICAL DIAGNOSIS OF SYPHILIS 327

TREATMENT 327

INDIVIDUAL PROPHYLAXIS AND THE PREVENTION OF SYPHILIS 331

PSYCHOLOGICAL AND SOCIAL ASPECTS OF SYPHILITIC INFECTION 331

NONSYPHILITIC TREPONEMATOSES 332

NONSYPHILITIC TREPONEMATOSES＆Thomas B．Turner 332

YAWS＆Thomas B．Turner 333

BEJEL＆Thomas B．Turner 336

PINTA＆Thomas B．Turner 337

RELAPSING FEVER＆Thomas B．Turner 338

TROPICAL ULCER＆Thomas B．Turner 341

RAT-BITE FEVERThomas B．Turner 342

SPIRILLARY RAT-BITE FEVER 342

STREPTOBACILLARY FEVER 343

THE LEPTOSPIROSES＆Paul B．Beeson 344

WEIL＇S DISEASE 345

PRETIBIAL FEVER 346

LEPTOSPIRAL MENINGITIS 347

GRIPPE-LIKE ILLNESS AND OTHER FORMS LEPTOSPIRAL INFECTION 347

PROTOZOAN INFECTIONS 348

AMEBIASIS＆Howard B．Shookhoff 348

COCCIDIOSIS＆Harold W．Brown 353

MALARIA＆L．T．Coggeshall 354

TRYPANOSOMIASIS＆David Weinman 361

AFRICAN TRYPANOSOMIASIS 361

CHAGAS＇DISEASE 363

LEISHMANIASIS＆Francis R．Dieuaide 365

KALA-AZAR 366

CUTANEOUS LEISHMANIASIS 370

AMERICAN MUCOCUTANEOUS LEISHMANIASIS 371

TOXOPLASMOSIS＆Harold W．Brown 372

CILIATE INFECTIONS＆Harold W．Brown 373

BALANTIDIASIS 373

METAZOAN INFECTIONS 375

METAZOAN INFECTIONS＆Harold W．Brown 375

THE PLATYHELMINTHES(FLATWORMS) 376

TREMATODE OR FLUKE INFECTIONS＆Harold W．Brown 376

INTESTINAL TREMATODES 376

Fasciolopsis Buski 376

Other Intestinal Trematodes 377

HEPATIC TREMATODES 377

Clonorchis Sinensis 377

Fasciola Hepatica 378

Other Hepatic Trematodes 379

PARAGONIMIASIS 379

SCHISTOSOMIASIS＆Harold W．Brown 380

INTESTINAL SCHISTOSOMIASIS 380

VESICAL SCHISTOSOMIASIS 382

SCHISTOSOME DERMATITIS 384

CESTODE OR TAPEWORM INFECTIONS＆Harold W．Brown 384

INTESTINAL CESTODIASIS 384

VISCERAL AND SOMATIC CESTODIASIS 387

Echinococcosis 387

Cysticercosis 389

Cenurosis 389

Sparganosis 390

THE NEMATHELMINTHES(ROUNDWORMS) 390

THE NEMATHELMINTHES＆Harold W．Brown 390

TRICHINOSIS＆George T．Harrell 390

TRICHURIASISHarold W．Brown 393

STRONGYLOIDIASISHarold W．Brown 395

ASCARIASISHarold W．Brown 396

VISCERAL LARVA MIGRANSHarold W．Brown 398

ENTEROBIASISHarold W．Brown 399

FILARIASISHarold W．Brown 401

BANCROFTIAN FILARIASIS 402

FILARIASIS MALAYI 404

LOAIASIS 404

ACANTHOCHEILONEMA PERSTANS 405

MANSONELLA OZZARDI 405

ONCHOCERCIASIS 405

DRACUNCULOSIS＆Harold W．Brown 406

HOOKWORM DISEASE＆Harold W．Brown 407

CREEPING ERUPTION＆Harold W．Brown 410

HETERODERA RADICICOLA＆Harold W．Brown 410

HIRUDINEA 411

HIRUDINIASIS＆Harold W．Brown 411

ARTHROPODS AND HUMAN DISEASE 412

SCABIES＆Harold W．Brown 412

PEDICULOSIS＆Harold W．Brown 412

FLEAS＆Harold W．Brown 413

CHIGGERS，REDBUGS OR HARVEST MITES＆Harold W．Brown 413

MYIASIS＆Harold W．Brown 413

VENENATING ARTHROPODS＆Harold W．Brown 414

ARTHROPODS AS MECHANICAL CARRIERS OF DISEASE＆Harold W．Brown 415

ARTHROPOD INTERMEDIATE HOSTS＆Harold W．Brown 416

DISEASES OF UNPROVED ETIOLOGY 417

SARCOIDOSIS＆Charles A．LeMaistre 417

MILIARY FEVER＆Russell L．Cecil 424

AINHUM＆Russell L．Cecil 424

MILK SICKNESS＆Russell L．Cecil 425

Diseases of Allergy 427

INTRODUCTION 427

RELATION OF ANTIGEN-ANTIBODY REACTIONS TO ALLERGIC DISEASES＆Elvin A．Kabat 427

HAY FEVER＆William B．Sherman 432

NONSEASONAL ALLERGIC RHINITIS，VASOMOTOR RHINITIS 436

ASTHMA＆William B．Sherman 437

DRUG ALLERGY＆Lewis Thomas 445

SERUM SICKNESS＆Lewis Thomas 448

CONTACT DERMATITIS＆William B．Sherman 451

URTICARIA＆William B．Sherman 453

ANGIONEUROTIC EDEMA＆William B．Sherman 454

ERYTHEMAS＆William B．Sherman 455

TOXIC ERYTHEMA 455

ERYTHEMA MULTIFORME 456

ERYTHEMA NODOSUM 456

Diseases of Connective Tissue 458

INTRODUCTION＆A．McGehee Harvey 458

SYSTEMIC LUPUS ERYTHEMATOSUS＆A．McGehee Harvey 460

DERMATOMYOSITIS＆A．McGehee Harvey 465

POLYARTERITIS＆A．McGehee Harvey 467

CRANIAL(TEMPORAL)ARTERITIS＆A．McGehee Harvey 471

PROGRESSIVE SYSTEMIC SCLEROSIS＆A．McGehee Harvey 472

SCLEREDEMA＆A．McGehee Harvey 474

THROMBOTIC THROMBOPENIC PURPURA＆A．McGehee Harvey 475

Diseases Due to Physical Agents 476

HEAT EXHAUSTION，HEAT STROKE AND HEAT CRAMPS＆＆Robert C．Darling 476

DECOMPRESSION ILLNESS＆Robert C．Darling 478

HIGH ALTITUDE SICKNESS＆Robert C．Darling 480

BLAST INJURY 483

MOTION SICKNESS＆Alvan L．Barach 484

ELECTRIC SHOCK＆W．J．McConnell 484

Diseases Due to Chemical Agents 487

CARBON MONOXIDE POISONING＆W．J．McConnell 487

SILO FILLER＇S DISEASE＆W．J．McConnell 489

CARBON TETRACHLORIDE POISONING＆W．J．McConnell 489

BENZENE POISONING＆W．J．McConnell 491

BERYLLIUM POISONING＆W．J．McConnell 492

MERCURY POISONING＆W．J．McConnell 494

ACUTE POISONING 494

SUBACUTE POISONING 495

INDUSTRIAL POISONING 495

ARSENIC POISONING＆W．J．McConnell 496

METAL FUME FEVER＆W．J．McConnell 498

LEAD POISONING＆Robert Kehoe 498

METHEMOGLOBINEMIA AND SULFHEMOGLOBINEMIA＆Henry Aranow，Jr 505

CHRONIC BROMIDE POISONING＆Henry Aranow，Jr 507

SALICYLATE POISONING＆Henry Aranow，Jr 508

METHYL ALCOHOL POISONING＆Henry Aranow，Jr 509

RADIATION INJURY＆Leon O．Jacobson 510

HYPERVITAMINOSIS＆Tom D．Spies 515

SNAKE VENOM POISONING＆Afranio do Amaral 517

FOOD POISONING＆G．M．Dack 521

INTRODUCTION 521

BACTERIAL FOOD POISONING 522

Preformed Toxins 522

(Botulism) 522

(Staphylococcal Food Poisoning) 524

Living Organisms 525

(Salmonella Food Poisoning) 525

(Microorganisms in Relation to Food Poisoning) 525

Deficiency Diseases 527

INTRODUCTION＆DeWitt Stetten，Jr 527

UNDERNUTRITION＆John B．Youmans 533

KWASHIORKOR＆John B．Youmans 537

VITAMIN A DEFICIENCY＆Tom D．Spies 539

VITAMIN B DEFICIENCIES＆Tom D．Spies 542

BERIBERI 542

PELLAGRA 545

RIBOFLAVIN DEFICIENCY 551

ACRODYNIA 552

BURNING FEET SYNDROME 553

PANTOTHENIC ACID DEFICIENCY 553

VITAMINS(FOLIC ACID AND VITAMIN B12)AND BLOOD REGENERATION 554

VITAMIN C DEFICIENCY＆Rustin Mcintosh 555

VITAMIN D DEFICIENCY＆A．Ashley Weech 559

VITAMIN E DEFICIENCY＆Tom D．Spies 563

VITAMIN K DEFICIENCY＆Tom D．Spies 564

MIXED DEFICIENCY DISEASES＆Tom D．Spies 565

SPRUE AND ALLIED MALABSORPTION SYNDROMES＆Eric E．Wollaeger 566

Diseases of Metabolism 573

INBORN ERRORS OF METABOLISM＆Alexander B．Gutman 573

INTRODUCTION 573

CONGENITAL METHEMOGLOBINEMIA 575

THE GLYCOGEN STORAGE DISEASES 576

GALACTOSEMIA 577

RENAL GLYCOSURIA 578

FRUCTOSURIA 578

PENTOSURIA 578

OXALOSIS 578

CYSTINOSIS 579

THE AMINOACIDURIAS 579

FANCONI SYNDROME 580

RENAL HYPOPHOSPHATEMIA 581

RENAL TUBULAR ACIDOSIS 582

ALKAPTONURIA AND OCHRONOSIS＆J．Murray Steele 583

PHENYLPYRUVIC OLIGOPHRENIA＆S．Z．Levine 584

HEPATOLENTICULAR DEGENERATION＆D．Denny-Brown 587

FAMILIAL PERIODIC PARALYSIS＆A．T．Milhorat 588

PORPHYRIA＆C．J．Watson 589

GOUT AND GOUTY ARTHRITIS＆Philip S．Hench 595

DIABETES INSIPIDUS＆John V．Taggart 608

DIABETES MELLITUS＆Robert F．Loeb 609

SPONTANEOUS HYPOGLYCEMIA＆Robert F．Loeb 632

OBESITY＆Cyril M．MacBryde 636

ATHEROSCLEROSIS＆David P．Barr 641

XANTHOMATOSIS＆David P．Barr 646

CARCINOID SYNDROME＆Albert Sjoerdsma 648

THE LIPOMATOSES＆Alexander B．Gutman 650

AMYLOIDOSIS＆Alexander B．Gutman 652

MELANOSIS AND MELANURIA＆Alexander B．Gutman 655

HEMOCHROMATOSIS＆Clement A．Finch 656

AGAMMAGLOBULINEMIA＆Charles A．Janeway 658

DEHYDRATION AND FLUID BALANCE：PHYSIOLOGICAL PRINCIPLES＆Robert W．Berliner 659

HYPONATREMIA＆Robert W．Berliner 665

HYPOKALEMIA＆Robert W．Berliner 667

ACIDOSIS＆P．H．Lavietes 669

ALKALOSIS＆P．H．Lavietes 674

Diseases of the Ductless Glands 676

INTRODUCTION＆Fuller Albright 676

DISEASES OF THE THYROID GLAND 679

NORMAL PHYSIOLOGY OF THE THYROID GLAND＆John B．Stanbury 679

TESTS OF THYROID FUNCTION 680

SIMPLE NONENDEMIC GOITER＆John B．Stanbury 682

ENDEMIC GOITER＆John B．Stanbury 682

HYPERTHYROIDISM＆John B．Stanbury 684

THYROIDITIS＆John B．Stanbury 690

THYROID NODULES AND MALIGNANT DISEASE OF THE THYROID＆John B．Stanbury 692

HYPOTHYROIDISM＆John B．Stanbury 693

DISEASES OF THE PARATHYROID GLAND 697

DISEASES OF THE PARATHYROID GLAND＆F．C．Bartter 697

PRIMARY HYPERPARATHYROIDISM 697

HYPOPARATHYROIDISM 699

TETANY 700

PSEUDOHYPOPARATHYROIDISM 702

DISEASES OF THE PITUITARY GLAND 704

THE HORMONES OF THE ANTERIOR LOBE＆A．T．Kenyan 704

HYPERPITUITARISM 709

ACROMEGALY AND GIGANTISM＆A．T．Kenyan 709

HYPOPITUITARISM＆A．T．Kenyan 714

SIMMONDS＇DISEASE 715

HYPOPITUITARISM DURING CHILDHOOD(INCLUDING ATELEIOSIS) 719

FROHLICH＇s SYNDROME 720

ANOREXIA NERVOSA 720

STEROID PHYSIOLOGY AND METABOLISM 722

STEROID PHYSIOLOGY AND METABOLISM＆Joseph W．Jailer 722

DISEASES OF THE ADRENAL GLANDS 727

INTRODUCTION＆George W．Thorn 727

DISEASES OF THE ADRENAL MEDULLA＆George W．Thorn 728

ADRENAL MEDULLARY HYPERFUNCTION 728

NONFUNCTIONING TUMORS ARISING FROM MEDULLARY TISSUE 730

DISEASES OF THE ADRENAL CORTEX＆George W．Thorn 731

INTRODUCTION 731

ADRENOCORTICAL HORMONE AND CORTICOTROPIN PREPARATIONS AVAILABLE FOR CLINICAL USE 732

HYPOFUNCTION OF THE ADRENAL CORTEX 733

ACUTE ADRENAL CORTICAL INSUFFICIENCY 733

CHRONIC ADRENAL CORTICAL INSUFFICIENCY 735

Primary Failure(Addison＇s Disease) 735

Chronic Adrenal Cortical Insufficiency Secondary to Pituitary Failure 737

Chronic Adrenal Cortical Insufficiency Secondary to Adrenalectomy 737

Chronic Adrenal Insufficiency Associated with Congenital Adrenal Cortical Hyperplasia 738

HYPERFUNCTION OF THE ADRENAL CORTEX 738

CUSHING＇S SYNDROME 738

ADRENOGENITAL SYNDROME AND ADRENAL VIRILISM 741

HYPERALDOSTERONISM 742

NONFUNCTIONING ADRENAL CORTICAL TUMORS 744

DISEASES OF THE SEX GLANDS 745

DISEASES OF THE MALE GONADS 745

DISEASES OF THE MALE GONADS＆Melvin M．Grumbach 745

SEX DETERMINATION AND SEX DIFFERENTIATION＆Melvin M．Grumbach 745

CHEMISTRY AND PHYSIOLOGY＆Melvin M．Grumbach 746

EVALUATION OF TESTICULAR FUNCTION＆Melvin M．Grumbach 747

PUBERTAL DEVELOPMENT IN THE MALE＆Melvin M．Grumbach 749

SEXUAL PRECOCITY＆Melvin M．Grumbach 750

HYPOGONADISM＆Melvin M．Grumbach 751

PRIMARY HYPOGONADISM 752

SECONDARY HYPOGONADISM 753

TREATMENT OF ANDROGEN DEFICIENCY＆Melvin M．Grumbach 755

CRYPTORCHIDISM＆Melvin M．Grumbach 755

IMPOTENCE＆Melvin M．Grumbach 757

MALE CLIMACTERIC＆Melvin M．Grumbach 757

ORCHITIS＆Melvin M．Grumbach 757

TUMORS OF TESTIS＆Melvin M．Grumbach 757

HERMAPHRODISM＆Melvin M．Grumbach 758

DISEASES OF THE FEMALE GONADS 759

DISEASES OF THE FEMALE GONADS＆C．Lee Buxton 759

MENARCHE＆C．Lee Buxton 760

OVARIAN ABNORMALITIES DURING ACTIVE MENSTRUAL LIFE＆C．Lee Buxton 763

THERAPY OF INADEQUATE HORMONAL FUNCTION OF THE OVARY 764

THE MENOPAUSE＆C．Lee Buxton 767

DISEASES OF THE THYMUS GLAND 771

DISEASES OF THE THYMUS GLAND＆A．McGehee Harvey 771

Diseases of the Digestive System 774

DISEASES OF THE MOUTH，SALIVARY GLANDS AND PHARYNX 774

DISEASES OF THE MOUTH＆John B．Erich 774

DISEASES AFFECTING THE ENTIRE MOUTH 774

DISEASES AFFECTING THE GUMS 778

DISEASES PECULIAR TO THE TONGUE 778

TUMORS OF THE ORAL CAVITY 779

DISEASES OF THE SALIVARY GLANDS＆John B．Erich 780

DISEASES OF THE PHARYNX＆John B．Erich 782

DISEASES OF THE ESOPHAGUS 784

DISEASES OF THE ESOPHAGUS＆Franz J．Ingelfinger 784

INTRODUCTION＆Franz J．Ingelfinger 784

CARDIOSPASM＆Franz J．Ingelfinger 785

OTHER MOTOR DISORDERS＆Franz J．Ingelfinger 787

MALIGNANT NEOPLASMS＆Franz J．Ingelfinger 788

PEPTIC ESOPHAGITIS＆Franz J．Ingelfinger 789

PEPTIC ULCER＆Franz J．Ingelfinger 790

OTHER FORMS OF ESOPHAGITIS AND STRICTURE＆Franz J．Ingelfinger 790

DIAPHRAGMATIC HERNIA＆Franz J．Ingelfinger 791

OTHER ESOPHAGEAL DISORDERS＆Franz J．Ingelfinger 793

DISEASES OF THE STOMACH 795

DISEASES OF THE STOMACH＆Walter L．Palmer 795

CONGENITAL ANOMALIES＆Walter L．Palmer 795

HYPERTROPHIC STENOSIS OF PYLORUS 795

In Infants 795

In Adults 796

DIVERTICULA 796

DIAPHRAGMATIC HERNIA 797

FOREIGN BODIES IN THE STOMACH 797

DISTURBANCES OF GASTRIC FUNCTION＆Walter L．Palmer 797

SENSORY DISTURBANCES 797

Hunger and Appetite 797

Anorexia Nervosa 798

Simmonds＇Disease 798

Nervous Vomiting 798

MOTOR DISTURBANCES 798

Acute Dilatation of the Stomach 798

NORMAL AND ABNORMAL VARIATIONS IN GASTRIC SECRETION 799

ACHLORHYDRIA 799

NONSPECIFIC INFLAMMATION OF THE STOMACH＆Walter L．Palmer 800

ACUTE GASTRITIS 800

ALCOHOLIC GASTRITIS 800

CHRONIC GASTRITIS 801

Superficial Gastritis 801

Atrophic Gastritis 801

Hypertrophic Gastritis 801

Gastritis of the Postoperative Stomach 802

Gastritis Simulating Carcinoma 802

SPECIFIC INFLAMMATION OF THE STOMACH＆Walter L．Palmer 802

CORROSIVE GASTRITIS 802

PHLEGMONOUS GASTRITIS 802

SCIRRHOUS OR SCLEROSING GASTRITIS 802

GASTRIC SYPHILIS 802

TUBERCULOSIS OF THE STOMACH 803

LYMPHOGRANULOMATOSIS 803

RARE INFECTIONS OF THE STOMACH 803

GASTRIC NEOPLASMS＆Walter L．Palmer 803

MESENCHYMAL TUMORS 803

EPITHELIAL TUMORS 804

Benign Mucosal Neoplasms 804

Carcinoma 805

PEPTIC ULCER＆Walter L．Palmer 811

JEJUNAL ULCER 825

POSTGASTRECTOMY SYNDROME 826

POSTVAGOTOMY SYNDROME 826

DISEASES OF THE INTESTINES 828

DISEASES OF THE DUODENUM＆Walter L．Palmer 828

VISCEROPTOSIS＆Walter L．Palmer 828

DIARRHEA＆Walter L．Palmer 829

CONSTIPATION＆Walter L．Palmer 829

IRRITABLE COLON＆Walter L．Palmer 830

DILATATION OF THE COLON＆Walter L．Palmer 834

DIVERTICULA OF THE INTESTINES＆Walter L．Palmer 835

ACUTE PSEUDOMEMBRANOUS ENTEROCOLITIS＆Walter L．Palmer 836

ULCERATIVE COLITIS＆Walter L．Palmer 836

REGIONAL ILEITIS＆Thomas P．Almy 839

APPENDICITIS＆I．S．Ravdin 842

INTESTINAL OBSTRUCTION＆Alton Ochsner 846

INTESTINAL NEOPLASMS＆Alton Ochsner 853

SMALL INTESTINE 853

Benign Tumors 853

Malignant Tumors 853

Carcinoma 854

Sarcoma(Carcinoid Tumors) 854

COLON AND RECTUM 855

Benign Tumors 855

Malignant Tumors 856

AFFECTIONS OF THE MESENTERY＆Alton Ochsner 857

STRUCTURAL ABNORMALITIES OF THE MESENTERY 857

MESENTERITIS 857

MESENTERIC HEMORRHAGE 857

MESENTERIC VASCULAR OCCLUSION 858

MESENTERIC LYMPHADENITIS 859

MESENTERIC SOLID TUMORS 859

MESENTERIC CYSTS 860

DISEASES OF THE LIVER 861

INTRODUCTION＆Franklin M．Hanger 861

JAUNDICE＆Franklin M．Hanger 861

OBSTRUCTIVE JAUNDICE 863

HEPATOGENOUS JAUNDICE 866

ACUTE INFECTIOUS HEPATITIS 867

NONINFECTIOUS HEPATOGENOUS JAUNDICE(TOXIC HEPATITIS) 871

ACUTE YELLOW ATROPHY OF THE LIVER 871

SUBACUTE YELLOW ATROPHY 872

ACHOLURIC JAUNDICE 873

RETENTION JAUNDICE 873

CAROTENEMIA 873

CIRCULATORY DISTURBANCES OF THE LIVER＆Arthur J．Patek，Jr 874

PASSIVE CONGESTION OF THE LIVER 874

CONGESTIVE(CARDIAC)CIRRHOSIS 875

PORTAL HYPERTENSION 876

THROMBOSIS OF THE PORTAL VEIN 877

THROMBOSIS OF THE HEPATIC VEINS 877

ASCITES IN DISEASES OF THE LIVER＆Arthur J．Patek，Jr 878

HEPATIC COMA＆Arthur J．Patek，Jr 879

CIRRHOSIS OF THE LIVER＆Arthur J．Patek，Jr 880

LAENNEC＇S CIRRHOSIS 880

BILIARY CIRRHOSES 884

Obstructive Biliary Cirrhosis 884

Primary Biliary Cirrhosis 885

POSTNECROTIC CIRRHOSIS 885

SYPHILITIC CIRRHOSIS 886

ZOOPARASITIC CIRRHOSIS 887

ABSCESS OF THE LIVER＆Arthur J．Patek，Jr 887

AMEBIC ABSCESS OF THE LIVER 887

PYOGENIC ABSCESS OF THE LIVER 887

NEOPLASMS OF THE LIVER＆Arthur J．Patek，Jr 888

PRIMARY CARCINOMA OF THE LIVER 888

SECONDARY CARCINOMA OF THE LIVER 889

BENIGN NEOPLASMS OF THE LIVER 890

CYSTS OF THE LIVER＆Arthur J．Patek，Jr 890

FATTY LIVER＆Arthur J．Patek，Jr 890

DISEASES OF THE GALLBLADDER AND BILE DUCTS 892

CHOLELITHIASIS＆C．J．Watson 892

CHOLECYSTITIS＆C．J．Watson 900

SUPPURATIVE CHOLANGITIS＆C．J．Watson 903

CARCINOMA OF THE GALLBLADDER AND BILE DUCTS＆C．J．Watson 904

CONGENITAL ABNORMALITIES OF THE BILE DUCTS＆C．J．Watson 905

DISEASES OF THE PANCREAS 907

INTRODUCTION＆Eric E．Wollaeger 907

CONGENITAL ANOMALIES＆Eric E．Wollaeger 908

ANNULAR PANCREAS 908

PANCREATIC HETEROTOPIA 908

ACUTE PANCREATITIS＆Eric E．Wollaeger 908

CHRONIC PANCREATITIS＆Eric E．Wollaeger 912

PANCREATIC CYSTS＆Eric E．Wollaeger 913

TUMORS OF THE PANCREAS＆Eric E．Wollaeger 914

ISLET CELL TUMORS 914

ULCEROGENIC ISLET CELL TUMORS 915

CARCINOMA 915

CYSTIC FIBROSIS OF THE PANCREAS＆Paul A．di Sant＇Agnese 917

DISEASES OF THE PERITONEUM 920

INTRODUCTION＆Frank Glenn 920

CONGENITAL ANOMALIES OF THE PERITONEUM＆Frank Glenn 920

GENERALIZED PERITONITIS＆Frank Glenn 921

SPECIAL TYPES OF PERITONITIS 924

MALIGNANT DISEASE OF THE PERITONEUM 927

ASCITES 927

Diseases of the Respiratory System 930

DISEASES OF THE NOSE 930

INFECTIONS OF THE ACCESSORY NASAL SINUSES＆Clyde A．Heatly 930

TUMORS OF THE NOSE AND NASOPHARYNX＆Clyde A．Heatly 931

DISEASES OF THE LARYNX 932

INTRODUCTION＆Clyde A．Heatly 932

COMMON LARYNGEAL DISORDERS＆Clyde A．Heatly 932

ACUTE LARYNGITIS 932

CONGENITAL LARYNGEAL STRIDOR 933

LARYNGISMUS STRIDULUS 933

FOREIGN BODIES IN THE LARYNX 933

PAPILLOMA OF THE LARYNX 933

COMMON LARYNGEAL DISORDERS OF ADULTS＆Clyde A．Heatly 934

CATARRHAL LARYNGITIS 934

BENIGN AND MALIGNANT TUMORS OF THE LARYNX 934

Benign Tumors 934

Malignant Tumors 934

Laryngeal Neuropathies 935

DISEASES OF THE BRONCHI 936

BRONCHITIS＆Dickinson W．Richards 936

ACUTE BRONCHITIS 936

CHRONIC BRONCHITIS 938

FIBRINOUS BRONCHITIS 941

BRONCHIOLITIS FIBROSA OBLITERANS 942

BRONCHIECTASIS＆Carl Muschenheim 942

FOREIGN BODIES IN THE BRONCHI＆Carl Muschenheim 949

DISEASES OF THE LUNGS 953

PULMONARY FUNCTION IN HEALTH AND DISEASE＆Dickinson W．Richards 953

CIRCULATORY DISTURBANCES IN THE LUNGS＆Dickinson W．Richards 961

PULMONARY EDEMA 961

PULMONARY HEMORRHAGE 963

PULMONARY EMBOLISM，PULMONARY INFARCTION AND THROMBOSIS 965

PULMONARY ARTERIAL HYPERTENSION AND PULMONARY ARTERIOSCLEROSIS 967

PULMONARY ARTERIOVENOUS FISTULA 969

PULMONARY ATELECTASIS＆Dickinson W．Richards 969

PULMONARY FIBROSIS＆Dickinson W．Richards 970

LOCALIZED PULMONARY FIBROSIS 971

DIFFUSE PULMONARY FIBROSIS 971

LOCALIZED AND DIFFUSE PULMONARY FIBROSIS 971

SYNDROME OF ALVEOLAR-CAPILLARY BLOCK＆Dickinson W．Richards 972

RADIATION PLEUROPNEUMONITIS＆Dickinson W．Richards 973

LIPOID PNEUMONITIS＆Dickinson W．Richards 973

ALLERGIC PNEUMONIA＆Dickinson W．Richards 974

EMPHYSEMA＆Dickinson W．Richards 974

ACUTE EMPHYSEMA 974

Acute Physiological Emphysema 974

Acute Vesicular Emphysema 974

CHRONIC EMPHYSEMA 975

Diffuse Obstructive Emphysema 975

Atrophic Emphysema 979

Other Forms of Alveolar Hypoventilation 979

Bullous Emphysema 979

Pulmonary Fibrosis and Emphysema 980

Localized Emphysema 980

SENILE LUNG 980

ABSCESS OF THE LUNG＆Herbert C．Maier 981

CYSTIC DISEASE OF THE LUNGS＆Herbert C．Maier 984

NEW GROWTHS IN THE LUNGS＆Herbert C．Maier 985

BENIGN TUMORS 985

CARCINOMA OF THE LUNG 985

TUMORS OF THE TRACHEA 989

PNEUMOCONIOSIS＆Ronald V．Christie 989

SILICOSIS 990

COAL MINER＇S PNEUMOCONIOSIS 993

ASBESTOSIS 993

BERYLLIOSIS 993

OTHER FORMS OF PNEUMOCONIOSIS 993

DISEASES OF THE PLEURA 995

SIMPLE HYDROTHORAX＆William H．Stead 995

PLEURISY＆William H．Stead 995

TUBERCULOUS PLEURISY 1000

FIBROSIS OF THE PLEURA 1002

PNEUMOTHORAX＆William H．Stead 1002

UNCOMMON PLEURAL DISEASES＆William H．Stead 1005

EMPYEMA＆William S．Tillett 1006

DISEASES OF THE MEDIASTINUM 1009

INFECTIONS OF THE MEDIASTINUM＆Carl Muschenheim 1009

ACUTE MEDIASTINITIS 1009

CHRONIC MEDIASTINITIS 1010

CYSTS AND TUMORS OF THE MEDIASTINUM＆Carl Muschenheim 1011

MEDIASTINAL HEMORRHAGE＆Carl Muschenheim 1013

MEDIASTINAL EMPHYSEMA＆Carl Muschenheim 1013

MEDIASTINAL HERNIA＆Carl Muschenheim 1013

DISEASES OF THE DIAPHRAGM 1015

INFLAMMATION OF THE DIAPHRAGM＆Carl Muschenheim 1015

SUBDIAPHRAGMATIC ABSCESS＆Carl Muschenheim 1016

PARALYSIS OF THE DIAPHRAGM＆Carl Muschenheim 1016

DIAPHRAGMATIC SPASM，TIC，AND FLUTTER＆Carl Muschenheim 1017

HICCUP 1017

TIC AND FLUTTER 1018

DIAPHRAGMATIC HERNIA＆Carl Muschenheim 1018

EVENTRATION OF THE DIAPHRAGM＆Carl Muschenheim 1020

HEPATODIAPHRAGMATIC INTERPOSITION OF THE COLON＆Carl Muschenheim 1020

Diseases of the Kidneys 1022

RENAL PHYSIOLOGY AND TESTS OF RENAL FUNCTION＆John V．Taggart 1022

NEPHRITIS＆Robert F．Loeb 1031

GLOMERULONEPHRITIS 1031

Acute Glomerulonephritis 1035

Chronic Glomerulonephritis 1039

ARTERIOLAR NEPHROSCLEROSIS 1046

MISCELLANEOUS NEPHRITIDES 1048

Acute Interstitial Nephritis 1048

Transfusion Nephritis 1048

Focal Nephritis 1048

Syphilitic Nephritis 1049

Arteriosclerotic Nephritis 1049

Radiation Nephritis 1049

Orthostatic Proteinuria 1049

THE NEPHROTIC SYNDROME＆Arnold S．Relman 1050

UREMIA＆Arnold S．Relman 1055

THE TOXEMIAS OF PREGNANCY＆George A．Perera 1060

URINARY SUPPRESSION＆John A．Luetscher，Jr 1061

HEMOGLOBINURIA AND MYOHEMOGLOBINURIA＆Thomas Hale Ham 1065

HEMOGLOBINURIA 1065

Examples of Hemoglobinuria from Intravascular Hemolysis 1066

MYOHEMOGLOBINURIA 1067

Comparison of Hemoglobinuria，Myohemoglobinuria and Other Pigments in the Urine 1068

HEMOLYTIC TRANSFUSION REACTIONS 1070

CIRCULATORY DISTURBANCES OF THE KIDNEY＆J．M．Hayman，Jr 1071

ANOMALIES AND MALFORMATIONS OF THE KIDNEYS＆J．M．Hayman，Jr 1072

NEPHROPTOSIS＆J．M．Hayman，Jr 1073

HYDRONEPHROSIS＆J．M．Hayman，Jr 1074

NON-PARASITIC CHYLURIA＆J．M．Hayman，Jr 1075

PNEUMATURIA＆J．M．Hayman，Jr 1075

BACTERIAL INFECTIONS OF THE KIDNEY AND URINARY PASSAGES＆J．M．Hayman，Jr 1076

NEPHROLITHIASIS＆J．M．Hayman，Jr 1079

CYSTS OF THE KIDNEY＆J．M．Hayman，Jr 1082

TUMORS OF THE KIDNEY＆J．M．Hayman，Jr 1083

Diseases of the Spleen and Reticuloendothelial System 1085

DISEASES OF THE SPLEEN 1085

INTRODUCTION＆Carl V．Moore 1085

ACQUIRED HEMOLYTIC ANEMIA(＂AUTOIMMUNE＂TYPE)＆Carl V．Moore 1086

ACQUIRED HEMOLYTIC ANEMIA(NONIMMUNE TYPE)ASSOCIATED WITH SPLENOMEGALY＆Carl V．Moore 1089

NEUTROPENIA ASSOCIATED WITH SPLENOMEGALY＆Carl V．Moore 1090

PANCYTOPENIA ASSOCIATED WITH SPLENOMEGALY＆Carl V．Moore 1090

CHRONIC CONGESTIVE SPLENOMEGALY＆Carl V．Moore 1091

MISCELLANEOUS ABNORMALITIES OF THE SPLEEN＆Carl V．Moore 1092

DISEASES OF THE RETICULOENDOTHELIAL SYSTEM 1095

CONDITIONS PRIMARILY AFFECTING LYMPH NODES＆Carl V．Moore 1095

LYMPHOSARCOMA AND RETICULUM CELL SARCOMA 1095

HODGKIN＇S DISEASE 1099

FOLLICULAR LYMPHOMA 1105

MYCOSIS FUNGOIDES 1105

EOSINOPHILIC GRANULOMA，LETTERERSIWE DISEASE，HAND-SCHULLER-CHRISTIAN DISEASE＆Carl V．Moore 1106

GAUCHER＇S DISEASE＆Carl V．Moore 1107

NIEMANN-PICK DISEASE＆Carl V．Moore 1109

MULTIPLE MYELOMA＆Alfred Gellhorn 1110

SOLITARY MYELOMA＆Alfred Gellhorn 1113

EXTRAMEDULLARY PLASMACYTOMAS＆Alfred Gellhorn 1113

CRYOGLOBULINEMIA＆Alfred Gellhorn 1114

MACROGLOBULINEMIA＆Alfred Gellhorn 1114

Diseases of the Blood 1116

INTRODUCTION．＆William B．Castle 1116

THE ANEMIAS＆William B．Castle 1117

ANEMIAS DUE TO INCREASED ERYTHROCYTE LOSS OR DESTRUCTION 1119

Anemias of Acute Erythrocyte Loss 1119

Anemias of Increased Erythrocyte Destruction 1119

ANEMIAS DUE TO DECREASED ERYTHROCYTE PRODUCTION 1129

Nutritional Deficiency of Erythropoiesis 1129

Endocrine Deficiency of Erythropoiesis 1134

Toxic Inhibition of Erythropoiesis 1134

Physical Injury of Erythropoiesis 1136

Mechanical Interference with Erythropoiesis 1136

Idiopathic Failure of Erythropoiesis 1137

HEMORRHAGIC DISEASES＆William B．Castle 1139

VASCULAR PURPURA 1141

THROMBOCYTOPENIC PURPURA 1142

COAGULATION DEFECTS 1144

Plasma Thromboplastin Formation Deficiencies 1144

Prothrombin and Prothrombin Accelerator Deficiencies 1145

Fibrinogen Deficiency 1147

Anticoagulants 1147

POLYCYTHEMIA＆William B．Castle 1148

RELATIVE POLYCYTHEMIA 1148

SECONDARY POLYCYTHEMIAS 1148

PRIMARY POLYCYTHEMIA 1150

MYELOPROLIFERATIVE DISORDERS INCLUDING MYELOID METAPLASIA＆William B．Castle 1152

MYELOID METAPLASIA 1152

THE LEUKOPENIC STATE AND AGRANULOCYTOSIS＆Carl V．Moore 1153

THE LEUKOPENIC STATE 1153

THE LEUKEMIAS＆Cyrus C．Sturgis 1159

CHRONIC GRANULOCYTIC LEUKEMIA 1161

Chronic Lymphocytic Leukemia 1164

ACUTE LEUKEMIA 1166

MONOCYTIC LEUKEMIA 1168

LESS COMMON VARIETIES OF LEUKEMIA AND ALLIED PATHOLOGICAL STATES 1169

Subleukemic(Aleukemic)Leukemia 1169

Lymphosarcoma Cell Leukemia 1170

Leukemoid Reactions 1170

Chloroma 1171

Diseases of the Cardiovascular System 1172

PATHOLOGICAL PHYSIOLOGY OF GENERALIZED CIRCULATORY FAILURE＆Eugene A．Stead，Jr 1172

CARDIAC DILATATION AND HYPERTROPHY＆Eugene A．Stead，Jr 1184

THE TREATMENT OF CONGESTIVE HEART FAILURE＆Eugene A．Stead，Jr 1184

ARTERIAL HYPERTENSION＆George A．Perera 1188

SYSTOLIC HYPERTENSION 1189

INTERMITTENT DIASTOLIC HYPERTENSION 1189

ESTABLISHED DIASTOLIC HYPERTENSION 1189

PRIMARY(ESSENTIAL)HYPERTENSION 1192

ARTERIAL HYPOTENSION＆George A．Perera 1198

CIRCULATORY COLLAPSE AND SHOCK＆Eugene A．Stead，Jr 1199

DISEASES OF THE HEART 1203

DISEASES OF THE PERICARDIUM＆Johnson McGuire 1203

ACUTE PERICARDITIS 1203

ACUTE NONSPECIFIC PERICARDITIS 1205

PERICARDIAL EFFUSION 1206

CHRONIC CONSTRICTIVE PERICARDITIS 1209

PERICARDIAL DISEASES AS A CAUSE OF ACUTE CARDIAC COMPRESSION 1211

OTHER CONDITIONS AFFECTING THE PERICARDIUM 1212

CONGENITAL HEART DISEASE＆Richard J．Bing 1212

CLASSIFICATION OF CONGENITAL HEART DISEASE 1220

RHEUMATIC HEART DISEASE＆F．C．Wood and H．F．Zinsser，Jr 1238

CHRONIC VALVULAR HEART DISEASE＆H．F．Zinsser，Jr．and F．C．Wood 1241

MITRAL VALVULAR DISEASE 1241

Mitral Stenosis 1241

Mitral Insufficiency 1250

AORTIC VALVULAR DISEASE 1251

Aortic Stenosis 1251

Aortic Insufficiency 1253

PULMONIC VALVULAR DISEASE 1254

Pulmonic Stenosis 1254

Pulmonic Insufficiency 1255

TRICUSPID VALVULAR DISEASE 1256

Tricuspid Insufficiency 1256

Tricuspid Stenosis 1257

SYPHILITIC AORTITIS AND ANEURYSM＆Hugh J．Morgan 1258

CLINICAL AND SUBCLINICAL FORMS OF AORTIC SYPHILIS 1258

Uncomplicated Syphilitic Aortitis 1259

Syphilitic Aortic Insufficiency 1259

Syphilis of the Ostia of Coronary Arteries 1260

Aneurysms of the Thoracic Aorta 1261

Abdominal Aneurysms 1263

ENDOCARDITIS＆Thomas H．Hunter 1264

DISEASES OF THE MYOCARDIUM＆Hugh J．Morgan 1269

MYOCARDITIS 1269

SENILE HEART DISEASE 1272

DISEASES OF THE CORONARY ARTERIES＆Herrman L．Blumgart 1274

THE PATHOGENESIS OF CARDIAC PAIN，WITH PARTICULAR REFERENCE TO CORONARY ARTERIOSCLEROSIS 1274

ANGINA PECTORIS 1276

ACUTE MYOCARDIAL INFARCTION 1283

CORONARY FAILURE：THE CLINICAL SYNDROME OF CARDIAC PAIN INTERMEDIATE BETWEEN ANGINA PECTORIS AND ACUTE MYOCARDIAL INFARCTION 1291

NEOPLASMS OF THE HEART＆Hugh J．Morgan 1293

CARDIAC ARRHYTHMIAS＆Harold J．Stewart 1294

SINUS NODE：NORMAL RHYTHM 1295

Sinus Irregularity or Sinus Arrhythmia 1295

Sinus Tachycardia 1296

Sinus Bradycardia 1296

Sino-Atrial Premature Contractions 1297

Sino-Atrial Block；Atrial Standstill 1297

Premature Contraction 1297

ATRIAL RHYTHMS 1298

Atrial Premature Contractions 1298

Blocked Atrial Premature Contractions 1299

Atrial Paroxysmal Tachycardia 1299

Atrial Fibrillation 1301

Paroxysmal Atrial Fibrillation 1304

Atrial Flutter 1305

ATRIOVENTRICULAR TISSUE 1307

Atrioventricular，Nodal or Junctional Premature Contractions 1307

Atrioventricular Paroxysmal Tachycardia 1308

Atrioventricular or Nodal Rhythm 1309

Wandering Pacemaker 1309

CONDUCTION DEFECTS 1309

Heart Block 1309

Second Degree Heart Block 1311

Complete Heart Block 1311

Bundle Branch Block 1313

Wolff-Parkinson-White Syndrome 1314

VENTRICULAR RHYTHMS 1314

Idioventricular Rhythm 1314

Ventricular Escape 1314

Ventricular Premature Contractions 1315

Interpolated Premature Contractions 1316

Ventricular Paroxysmal Tachycardia 1317

Ventricular Fibrillation 1319

PULSUS ALTERNANS 1320

COUPLED RHYTHM 1321

NEUROCIRCULATORY ASTHENIA＆Arthur C．DeGraff 1321

CAROTID SINUS SYNCOPE＆Arthur C．DeGraff 1323

DISEASES OF THE PERIPHERAL VESSELS 1324

GENERAL CONSIDERATIONS＆R．W．Wilkins 1324

PERIPHERAL VASCULAR DISEASES DUE TO ORGANIC ARTERIAL OBSTRUCTION 1329

Thromboangitis Obliterans 1329

PULSELESS DISEASE 1331

PERIPHERAL ARTERIOSCLEROSIS 1332

ARTERIAL EMBOLISM 1332

PERIPHERAL ARTERITIS AND GANG3ENE IN SYSTEMIC INFECTIONS 1333

PERIPHERAL VASCULAR DISEASES DUE TO ABNORMAL VASOCONSTRICTION OR VASODILATATION＆R．W．Wilkins 1334

RAYNAUD＇S DISEASE 1334

ACROCYANOSIS 1336

ERGOTISM 1337

ERYTHROMELALGIA 1337

PERIPHERAL VASCULAR DISEASES DUE TO EXPOSURE TO COLD＆R．W．Wilkins 1338

TRENCH FOOT AND IMMERSION FOOT 1338

CHILBLAIN AND PERNIO 1339

FROSTBITE 1340

PERIPHERAL VASCULAR DISEASES DUE TO ABNORMAL COMMUNICATIONS BETWEEN ARTERIES AND VEINS＆R．W．Wilkins 1341

ARTERIOVENOUS FISTULA 1341

GLOMANGIOMA OR GLOMUS TUMOR 1341

DISEASES OF THE PERIPHERAL VEINS＆R．W．Wilkins 1342

VARICOSE VEINS 1342

PHLEBOTHROMBOSIS AND THROMBOPHLEBITIS 1342

DISEASES OF THE PERIPHERAL LYMPHATIC VESSELS＆R．W．Wilkins 1345

LYMPHANGITIS 1345

LYMPHEDEMA 1345

ARTERIOSCLEROSIS＆Hugh J．Morgan 1346

Diseases of the Locomotor System 1351

DISEASES OF THE MUSCLES 1351

THE DYSTROPHIES＆A．T．Milhorat 1351

PROGRESSIVE MUSCULAR DYSTROPHY 1351

MYOTONIA CONGENITA 1353

AMYOTONIA CONGENITA 1354

MYOTONIA ATROPHICA 1354

MYOSITIS＆Charles H．Slocumb 1354

PARENCHYMATOUS MYOSITIS 1354

Suppurative Myositis(Primary Suppurative Myositis) 1355

(Secondary Suppurative Myositis) 1355

Nonsuppurative Myositis(Dermatomyositis) 1355

(Progressive Myositis Fibrosa) 1355

(Trichinous Myositis) 1356

INTERSTITIAL MYOSITIS 1356

Myositis Ossificans 1356

MYOPATHIES＆Charles H．Slocumb 1357

THE FIBROSITIS SYNDROME＆Wallace Graham 1357

DISEASES OF THE JOINTS 1361

ARTHRITIS＆Russell L．Cecil 1361

ARTHRITIS DUE TO INFECTION 1361

RHEUMATOID ARTHRITIS 1362

Clinical Variants of Rheumatoid Arthritis 1376

DEGENERATIVE JOINT DISEASE＆Russell L．Cecil 1379

SPECIAL FORMS 1382

Osteoarthritis of the Hip 1382

Heber-den＇s Nodes 1382

Primary Generalized Osteoarthritis 1383

Hypertrophic Spondylitis 1383

NEUROGENIC ARTHROPATHY＆Russell L．Cecil 1383

NEOPLASMS OF THE JOINTS＆Russell L．Cecil 1384

MECHANICAL DERANGEMENTS OF JOINTS＆Russell L．Cecil 1384

MISCELLANEOUS FORMS OF ARTHRITIS＆Russell L．Cecil 1384

THE PAINFUL SHOULDER＆Russell L．Cecil 1385

CALCIFIC TENDINITIS 1385

ADHESIVE PERITENDINITIS 1386

ARTHRITIS OF THE SHOULDER 1386

THE SHOULDER-HAND SYNDROME 1386

DISEASES OF THE BONES 1388

OSTEOPOROSIS＆Walter Bauer and Frederic C．Bartter 1388

FRAGILITAS OSSIUM＆Walter Bauer and Frederic C．Bartter 1390

OSTEOMALACIA＆Walter Bauer and Frederic C．Bartter 1392

OSTEITIS FIBROSA CYSTICA GENERALISATA＆Walter Bauer and Frederic C．Bartter 1394

FIBROUS DYSPLASIA OF BONE＆Walter Bauer and Frederic C．Bartter 1396

OSTEITIS DEFORMANS＆Walter Bauer and Frederic C．Bartter 1398

LEONTIASIS OSSEA＆Walter Bauer and Frederic C．Bartter 1401

DYSCHONDROPLASIA＆Walter Bauer and Frederic C．Bartter 1401

HEREDITARY DEFORMING CHONDRODYSPLASIA 1402

OLLIER＇S DISEASE 1402

ACHONDROPLASIA＆Walter Bauer and Frederic C．Bartter 1403

MARFAN＇S SYNDROME＆Walter Bauer and Frederic C．Bartter 1405

OXYCEPHALY＆Walter Bauer and Frederic C．Bartter 1406

HYPEROSTOSIS FRONTALIS INTERNA＆Walter Bauer and Frederic C．Bartter 1408

HYPERTROPHIC OSTEOARTHROPATHY＆Walter Bauer and Frederic C．Bartter 1409

TIETZE＇S SYNDROME＆Walter Bauer and Frederic C．Bartter 1412

TUMORS OF BONE＆Bradley L，Coley 1412

Diseases of the Nervous System 1417

IMPORTANT SYMPTOMS AND SIGNS 1417

HEADACHE＆Harold G．Wolff 1417

MECHANISMS OF HEADACHE FROM INTRACRANIAL SOURCES 1418

Lumbar Puncture Headache：Its Mechanism and Management 1418

Headache with Brain Tumor—With or Without Increased Intracranial Pressure 1419

HEADACHES ARISING CHIEFLY FROM EXTRACRANIAL STRUCTURES 1420

Vascular Headaches 1420

Migraine Syndrome 1421

Muscle Contraction Headaches 1422

Recurrent(＂Chronic＂)Post-Traumatic Headache 1423

Headaches Associated with Arterial Hypertension 1423

Nasal and Paranasal Structures as Sources of Headache and Other Head Pain 1424

Head Pain and Disease of the Teeth 1424

Head Pain and Disease of the Ear 1425

The Eye as a Source of Headache and Other Pain 1425

CONVULSIVE STATES 1426

EPILEPSY＆William G．Lennox 1426

SYNCOPE＆George L．Engel 1434

NARCOLEPSY＆Donald J．Simons 1437

APHASIA＆Lamar Roberts 1440

HEMIPLEGIA＆Fletcher H．McDowell 1444

DELIRIUM AND ALLIED STATES＆Desmond Curran 1449

DEMENTIA＆Harold G．Wolff 1452

DISEASES OF THE MOTOR TRACTS 1456

PROGRESSIVE SPINAL MUSCULAR ATROPHY＆Bernard J．Alpers 1456

FAMILIAL PROGRESSIVE SPINAL MUSCULAR ATROPHY OF CHILDHOOD＆Bernard J．Alpers 1457

NEURAL FORM OF PROGRESSIVE MUSCULAR ATROPHY＆Bernard J．Alpers 1458

AMYOTROPHIC LATERAL SCLEROSIS＆Bernard J．Alpers 1459

PRIMARY LATERAL SCLEROSIS＆Bernard J．Alpers 1460

PROGRESSIVE BULBAR PARALYSIS＆Bernard J．Alpers 1461

HEREDITARY，FAMILIAL，AND CONGENITAL DISEASES 1463

MALFORMATIONS OF THE CENTRAL NERVOUS SYSTEM＆Robert B．Aird 1463

MALFORMATIONS OF THE BRAIN 1463

MALFORMATIONS OF THE SPINAL CORD 1464

Spina Bifida 1464

Other Malformations of the Spinal Cord 1465

CEREBRAL PALSY＆Harold G．Wolff 1465

HEREDITARY SPINAL AND CEREBELLAR ATAXIA＆Robert B．Aird 1466

FRIEDREICH＇S ATAXIA 1466

OTHER HEREDITARY ATAXIAS 1467

MENTAL DEFICIENCY＆George A．Jervis 1467

TYPES OF MENTAL DEFICIENCY 1468

Undifferentiated Mental Deficiency 1468

Amaurotic Family Idiocy 1468

Gargoylism 1469

Tuberosclerosis 1470

Mongolism 1470

HEREDITARY CHOREA＆D．Denny-Brown 1471

FAMILIAL SPASTIC PARALYSIS 1472

PROGRESSIVE FAMILIAL NEUROTIC ATROPHIES 1472

DYSTONIA MUSCULORUM DEFORMANS 1472

DISEASES OF VARIOUS ETIOLOGY 1474

MYASTHENIA GRAVIS＆A．McGehee Harvey 1474

SYPHILIS OF THE CENTRAL NERVOUS SYSTEM＆Herbert Koteen 1480

CLINICAL SUBDIVISIONS OF NEUROSYPHILIS 1481

Asymptomatic Neurosyphilis；Syphilitic Meningitis 1482

Vascular Neurosyphilis 1482

General Paresis 1483

Tabes Dorsalis 1485

Optic Atrophy 1486

Rare Forms of Neurosyphilis 1487

MENINGITIS＆Chester S．Keefer 1488

Nonsuppurative Meningitis 1492

MYELITIS＆Raymond D．Adams 1494

MYELITIS DUE TO FILTERABLE VIRUSES 1495

MYELITIS(MYELOPATHY)OF UNKNOWN ETIOLOGY 1495

Demyelinative and Degenerative(Necrotic)Myelopathy 1495

Acute Disseminated Postinfectious and Posvaccinial Myelopathy 1497

MYELITIS SECONDARY TO INFLAMMATORY DISEASES OF THE MENINGES 1497

Pyogenic or Suppurative Myelitis 1497

Tuberculous Myelitis 1498

Myelitis Due to Miscellaneous Fungous and Parasitic Diseases and Others of Unknown Cause 1498

ACUTE IDIOPATHIC POLYNEURITIS＆Raymond D．Adams 1501

COMBINED SYSTEM DISEASE＆D．Denny-Brown 1505

MULTIPLE SCLEROSIS＆George A．Schumacher 1509

ACUTE CHOREA＆Walter O．Klingman 1514

PARALYSIS AGITANS＆D．Denny-Brown 1517

TIC AND TORTICOLLIS＆D．Denny-Brown 1521

MUSCLE SPASMS，PROFESSIONAL CRAMP AND BACKACHE＆Thomas H．Holmes 1521

DIFFUSE AND FOCAL DISEASES OF THE SPINAL CORD 1525

AFFECTIONS OF THE BLOOD VESSELS OF THE SPINAL CORD＆H．Houston Merritt 1525

VASCULAR LESIONS OF THE SPINAL CORD 1525

ARTERIOSCLEROSIS OF THE SPINAL VESSELS 1525

MYELOMALACIA 1525

HEMATOMYELIA 1526

TUMORS OF THE SPINAL CORD AND SPINAL CANAL＆Branson S．Ray 1527

DEVELOPMENTAL ANOMALIES OF THE CERVICOMEDULLARY JUNCTURE＆Branson S．Ray 1532

SYRINGOMYELIA＆Fred Plum 1534

DIFFUSE AND FOCAL DISEASES OF THE BRAIN 1537

AFFECTIONS OF THE BLOOD VESSELS OF THE BRAIN＆H．Houston Merritt 1537

CEREBRAL HEMORRHAGE 1537

CEREBRAL THROMBOSIS 1537

CEREBRAL EMBOLUS 1538

MANAGEMENT OF CEREBRAL VASCULAR ACCIDENTS 1538

COMMON SYNDROMES OF CEREBRAL VASCULAR ACCIDENTS 1543

VASCULAR LESIONS OF THE BRAIN STEM 1545

PSEUDOBULBAR PALSY 1546

CEREBRAL VENOUS LESIONS 1547

SUBDURAL HEMATOMA 1548

SPONTANEOUS SUBARACHNOID HEMORRHAGE＆George A．Wolf，Jr 1550

INTRACRANIAL TUMORS＆A．Earl Walker 1551

INTRACRANIAL ABSCESSES＆A．Earl Walker 1560

BENIGN INTRACRANIAL HYPERTENSION＆Bronson S．Ray 1562

INTERNAL HYDROCEPHALUS＆D．D．Matson 1564

BIRTH INJURIES OF THE CENTRAL NERVOUS SYSTEM＆D．D．Matson 1566

BRAIN 1566

SPINAL CORD 1567

DISEASES OF NERVE ROOTS，PLEXUSES AND NERVES 1569

OPTIC NEURITIS AND RETROBULBAR NEURITIS＆E．Charles Kunkle 1569

OPTIC ATROPHY＆E．Charles Kunkle 1571

TRIGEMINAL NEURALGIA＆E．Charles Kunkle 1572

MENIERE＇S DISEASE＆E．Charles Kunkle 1573

BELL＇S PALSY＆E．Charles Kunkle 1575

HORNER＇S SYNDROME＆E．Charles Kunkle 1577

GLOSSOPHARYNGEAL NEURALGIA＆E．Charles Kunkle 1578

DISEASES OF OTHER ROOTS AND NERVES 1580

NEURITIS＆E．Charles Kunkle 1580

SCALENUS ANTICUS SYNDROME＆A．B．Baker 1584

SHOULDER-HAND SYNDROME＆Harold G．Wolff 1585

CERVICAL AND LUMBOSACRAL RADICULITIS，INCLUDING THE SYNDROME DUE TO DISPLACEMENT OF AN INTERVERTEBRAL DISK＆Kendall B．Corbin 1586

RADICULITUS DUE TO PROTRUSION OF THE INTERVERTEBRAL DISKS 1587

Protrusion of Lumbar Disks 1587

Protrusion of Cervical Disks 1588

CERVICAL SPONDYLOSIS＆W．R．Brain 1590

NEUROMAS＆A．B．Baker 1592

VASOMOTOR AND TROPHIC DISORDERS 1594

CAUSALGIA＆Theodore Lidz 1594

ACROPARESTHESIA＆George D．Gammon 1595

FACIAL HEMIATROPHY＆Fred Plum 1596

HEMIFACIAL SPASM＆Fred Plum 1597

THE PSYCHONEUROSES 1599

THE PSYCHONEUROSES＆Lawrence C．Kolb 1599

PERSONALITY DISORDERS 1618

ADDICTIONS 1620

ALCOHOLISM＆Sam Bernard Wortis 1620

ACUTE ALCOHOLISM 1623

CHRONIC ALCOHOLISM 1625

MARIHUANA INTOXICATION OR ADDICTION＆Sam Bernard Wortis 1630

BARBITURATE POISONING＆Harris Isbell 1631

ACUTE BARBITURATE POISONING 1632

CHRONIC BARBITURATE INTOXICATION(BARBITURATE ADDICTION) 1634

OPIUM POISONING＆Harris Isbell 1637

ACUTE OPIUM POISONING 1637

CHRONIC OPIUM POISONING(NARCOTIC ADDICTION) 1638

COCAINE POISONING＆Harris Isbell 1643

ACUTE COCAINE POISONING 1643

CHRONIC COCAINE POISONING 1643

CHRONIC AMPHETAMINE POISONING＆Harris Isbell 1645

THE PSYCHOSES 1646

GENERAL CONSIDERATIONS＆John C．Whitehorn 1646

THE FUNCTIONAL UNDERSTANDING OF PSYCHOTIC REACTIONS＆John C．Whitehorn 1647

STATISTICAL DIAGNOSTIC CLASSIFICATION＆John C．Whitehorn 1652

SPECIAL PSYCHIATRIC CONDITIONS＆John C．Whitehorn 1653

PSYCHIATRIC THERAPY＆John C．Whitehorn 1657

ELECTRIC SHOCK TREATMENT IN PSYCHIATRIC THERAPY＆Peter F．Regan 1659

Appendix and Index 1661

NORMAL LABORATORY VALUES OF CLINICAL IMPORTANCE 1661

INDEX 1667